RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CDKN2B
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
DNA methylation analysis; qRT-PCR; Immunoblot etc.
Target
NA
Pathway
NA
PubMed ID
Title
Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung
Year
2014
Function
"IPF fibroblasts exhibit global differences in DNA methylation that may contribute to the excessive fibroproliferation associated with this disease. DNA methylation differences in 3 genes (CDKN2B, CARD10, and MGMT) corresponded with differences in gene expression at the mRNA and protein level."